Isochlorogenic Acid C Restrains Erk/JNK/NF-κB Signaling to Alleviate Inflammatory Response and Promote Cell Apoptosis

Isochlorogenic acid C (ICAC) is found in a variety of natural foods and medicinal plant materials. This study aims to validate the biological activity isochlorogenic limiting inflammation by Erk/JNK/NF-κB pathway. In this study, TNF-α-induced human fibroblast-like synoviocytes collagen-induced arthritis animal models were used perceive potential anti-inflammation mechanism ICAC. The role was evaluated observing migration, invasion ability, apoptotic cells humans analysing foot swelling, joint index, histopathological changes RA model. results reveal that ICAC inhibited proliferation promoted their apoptosis. also blocked nuclear transfer NF-κB, Erk, JNK. It observed significantly degree posterior swelling CIA, reducing scores, bone tissue injury, articular synovitis. may promote cell apoptosis inhibit hyperactivation inflammatory alleviate inflammation-induced synovial through